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KMID : 1035520210090020093
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Brain Tumor Research and Treatment : BTRT
2021 Volume.9 No. 2 p.93 ~ p.99
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Intracranial Tumors Associated With IgG4-Related Disease
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Kim Dong-Kyu
Kim Se-Hoon
Kim Eui-Hyun
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Abstract
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IgG4-related disease (IgG4-RD) is an immune-mediated inflammatory condition which is characterized by dense lymphoplasmacytic infiltrations with a predominance of IgG4 plasma cells in the affected tissue. Although pachymeninx and pituitary gland are the most common sites where IgG4-RD infiltrates, the associations with IgG4-RD and a true intracranial tumor have not been yet reported in literature. Herein, we report two cases with intracranial tumors associated with IgG4-RD; a 36-year-old male patient with a huge meningioma and another 54-year old woman with a pituitary macroadenoma. Pathological examination revealed their tumors were substantially infiltrated by IgG4 plasma cells indicating its possible relation with IgG4-RD.
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KEYWORD
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IgG4-related disease, Meningioma, Pituitary adenoma
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